The new restaurant will be built over two floors in an unused part of the building that houses the Lendal Cellars pub, which will remain there as part of the development.
Building work is currently taking place on the building, which is Grade 2 listed and the restaurant is due to open in July.
The restaurant has already got its restaurant insurance quotes, suppliers and manufacturers and has already begun the search for new front of house staff and chefs.
Jamie has said that he had wanted to open a branch in York for some time now. He said, “York is such a beautiful city – I used to go there on holiday as a kid and I’ve wanted to find the right site there for a while.
“We’re in a fantastic location and it’s really going to be a wonderful place to eat, one of the jewels of the Jamie’s Italian collection.
“We’re now recruiting and starting to train the very best local waiting staff, chefs and front-of-house staff, so we hope people will come and join us.”
The Tudor roof trusses, exposed brick walls and its other original features would be preserved, says a spokeswoman for the firm. The restaurant will also have an open kitchen and have an outside dining area.
Michael Hjort, York restaurateur, who is a secretary of York Hospitality Association and also organises the yearly York Food and Drink Festival, said “York has a large number of chain operations, of which the Jamie’s Italian restaurant will be another one.
“There is certainly no harm in competition and I think it will be a welcome addition to the offer York gives to its visitors.”
The parts of the building where the restaurant is taking place have previously been out of use for a few years.
There are currently 26 other Jamie’s Italian restaurants across the UK, as well as branches in Dubai and Sydney.